Username:    Password:      Remember me       

Cancer Forums

A website for discussions about any type of cancer, including lung cancer, breast cancer, mesothelioma, prostate cancer, laryngeal cancer, leukemia, lymphoma, multiple myeloma and others

SearchSearch   DigestsEmail Digests     Register to postRegister to post   ProfileProfile   Check private messagesCheck private messages   Log inLog in 
stages of CLL What is this ?

 
Post new topic   Reply to topic    Cancer Forums Forum Index -> Leukemia Forum


Author
beebeknights
New User


Joined: 25 Dec 2004
Posts: 1
Location: South Dakota
PostPosted: Sat Dec 25, 2004 11:15 pm    Post subject: stages of CLL Reply with quote
My name is Greg. I have CLL. I took chemo treatments 3 years ago and was OK until this fall. The Dr. said my bone marrow is "70% packed". Is this an indication of what stage my cancer is at? I am looking into a bone marrow transplant.
Back to top
leo
Site Admin


Joined: 23 Sep 2004
Posts: 1574
PostPosted: Sun Dec 26, 2004 1:44 pm    Post subject: CLL staging systems: Rai and Binet Reply with quote
Hello

Thanks for posting. Essentially with CLL your bone marrow will have a lot of CLL, and this does not change your stage. What will change your stage is the consequence of the bone marrow disease: anemia, thrombocitopenia, enlarged spleen and/or liver, etc.

There are two staging systems for CLL: Rai and Binet.

Rai staging System

Stage 0
Stage 0 chronic lymphocytic leukemia: absolute lymphocytosis (>15,000 per cubic millimeter) without adenopathy, hepatosplenomegaly, anemia, or thrombocytopenia.

Stage I
Stage I chronic lymphocytic leukemia: absolute lymphocytosis with lymphadenopathy without hepatosplenomegaly, anemia, or thrombocytopenia.

Stage II
Stage II chronic lymphocytic leukemia: absolute lymphocytosis with either hepatomegaly or splenomegaly, with or without lymphadenopathy.

Stage III
Stage III chronic lymphocytic leukemia: absolute lymphocytosis and anemia (hemoglobin <11 g/dL) with or without lymphadenopathy, hepatomegaly, or splenomegaly.

Stage IV
Stage IV chronic lymphocytic leukemia: absolute lymphocytosis and thrombocytopenia (<100,000 per cubic millimeter) with or without lymphadenopathy, hepatomegaly, splenomegaly, or anemia.

Binet classification

Clinical stage A: no anemia or thrombocytopenia and fewer than three areas of lymphoid involvement (Rai stages 0, I, and II)

Clinical stage B: no anemia or thrombocytopenia with three or more areas of lymphoid involvement (Rai stages I and II)*

Clinical stage C: anemia and/or thrombocytopenia regardless of the number of areas of lymphoid enlargement (Rai stages III and IV)

References

1. Rai KR, Sawitsky A, Cronkite EP, et al.: Clinical staging of chronic lymphocytic leukemia. Blood 46 (2): 219-34, 1975.
2. Binet JL, Auquier A, Dighiero G, et al.: A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 48 (1): 198-206, 1981.
_________________
Leonardo F - Webmaster Cancer Forums
Disclaimer: this information is for informational purposes only. It is not medical advice.
Back to top


Display posts from previous:   
Post new topic   Reply to topic    Cancer Forums Forum Index -> Leukemia Forum All times are GMT - 5 Hours
Page 1 of 1

 
Jump to:  
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum
Download our Toolbar



About the author
E-mail webmaster
Terms, conditions and privacy policy		 We subscribe to the HONcode principles of the HON Foundation. Click to verify. We subscribe to the HONcode principles. Verify here. All content and posts are copyright.
Powered by phpBB © 2001, 2002 phpBB Group