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New Info on GBM research! What is this ?

 
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artnut
Regular


Joined: 07 Aug 2005
Posts: 19
Location: West Virginia
PostPosted: Wed Aug 24, 2005 6:05 pm    Post subject: New Info on GBM research! Reply with quote
I was reading an article on the newest testing for ways to treat GBM and thought those afflicted with this dreaded cancer might find hope that there could be an effective treatment on the horizon.
http://www.rxpgnews.com/research/cancer/brain/glioblastomamultiforme/article_2059.shtml
Let's keep praying for a cure! Very Happy
Ann
Husband dx with GBM IV 7/05/05
1 week into radiation and Temodar treatment
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gdpawel
Senior User


Joined: 15 Jan 2005
Posts: 123
Location: Pennsylvania
PostPosted: Sat Nov 12, 2005 9:30 pm    Post subject: Re: New Info on GBM research Reply with quote
Paul Mischel of the University of California at Los Angeles and his colleagues reported in the New England Journal of Medicine that they have developed a test for brain tumor tissue that predicts which patients will be sensitive to chemotherapy drugs that block a key protein called EGFR in the cancer cells of glioblastomas. Mischel said this will help prevent patients from having therapies that are much more toxic and less beneficial.

It's the latest in a series of papers relating gene mutations or changes in gene expression with response to the EGFR tyrosine kinase inhibitors Gefitinib (Iressa) and Erlotinib (Tarceva). What's interesting is that, in every paper, something different correlates.

A test of brain tissue can detect whether patients are good candidates for the treatments, which can help them to live nearly a year longer than they would without the treatment. However, the test can also spare those for whom the toxic treatments would only intensify suffering.
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