HER2NEU positive and Breast Cancer

Annie S · Regular Joined: 15 Feb 2005 Posts: 18

Hello,

I am interested in knowing if any other women who have Breast Cancer and are [u]HER2NEU positive[/u] have taken Taxol or any type's of chemo for their BC. I am also [u]estrogen receptor negative[/u] and [u]progesteron receptor negative[/u], my BC was not involved with lymph knodes and margins were clear. If anyone out there has similiar or same, please contact me. AESLINY@AOL.COM. My doctor would lik eme to do the Taxene;s but there is not much information on women who are HER2NEU positive on this type of chemo.
I apprecaite any help on this subject.
Thank you
Annie <3

leo · Site Admin Joined: 23 Sep 2004 Posts: 1574

Annie,

I will move your question to the Breast Cancer area, as you are much more likely to get answers there.

best regards,
Leo
_________________
Leonardo F - Webmaster Cancer Forums
Disclaimer: this information is for informational purposes only. It is not medical advice.

Minnlady13

Hi Anne, I am glad that Leo moved your question to our board. I am sure you will get several responses. Unfortunately, I cannot help you. The HER2NEU testing was done after I was diagnosed and I was ER/PR+. Good luck in getting the information you need. Lauri
_________________
Diagnosed 4/11/1996
Lumpectomy, 6 mm tumor
Neg. nodes
ER/PR+
33 rads
Tamoxifen, 5 yrs.
NED

penelopez · Senior User Joined: 11 Oct 2004 Posts: 165

Hi Annie,

Have you tried this site? It is for her2neu positive women, so you should gets lots of feedback. www.her2support.org

Hugs,

Margie

Muttsmom

Hi Annie,
I'm Her2 -, but I have a friend right now taking Taxotere who is Her2+++ and another friend has taken both Taxol and Taxotere and also the Herceptin and both tolerated the Taxol and Taxotere real well.
Nancy
_________________
Nancy
2/14/02 ILC 43 - 5.5 cm 9+/16 nodes
Stage IIIA er/pr+ Her2-
2/02 MRM
FECx6 radsx33
Tamoxifen - Arimidex (chemo induced menopause)
4/03 SM w/bilat. recon.
9/03 expanders removed
5/04 repair reconst. disaster
10/04 Actonel for bone/joint pain from Arimidex
NED - 5 years
3/07 Diabetes
In memory of Kim 12/1/04

Muttsmom

Hi Annie,
I e-mailed a friend of mine who's taking Taxotere now and is Her2 positive. She's not on line, but I feel certain she will come on and post and hopefully help answer some questions for you.
Take care
nancy

p.s. Her name is Christa
_________________
Nancy
2/14/02 ILC 43 - 5.5 cm 9+/16 nodes
Stage IIIA er/pr+ Her2-
2/02 MRM
FECx6 radsx33
Tamoxifen - Arimidex (chemo induced menopause)
4/03 SM w/bilat. recon.
9/03 expanders removed
5/04 repair reconst. disaster
10/04 Actonel for bone/joint pain from Arimidex
NED - 5 years
3/07 Diabetes
In memory of Kim 12/1/04

Bbeth69 · New User Joined: 13 Jan 2005 Posts: 5

My cancer was diagnosed as Her+++ and ER-/PR-. My threatment following mastectomy & node disection (8/11+) consisted of 4 rounds of AC (Adriamycin & Cytoxin) 3 weeks apart. When that was done I received 4 rounds of Taxotere 3 weeks apart. When all of that was finished I had weekly Herceptin infusions for a year. I tolerated it all very well. I did not have any nausea since they gave me drugs (can't remember the name rght now). I did loose my hair but it returned when I began the taxotere. The nurse said that this was very unusual (leave it to me!). The taxotere also caused a numbness in my fingers and toes that has since disappeared. I also would feel exhauseted the third day after the treatments. My blood counts did not drop dangerously low since they gave me Neulasta or Procrit the day after the chemo. The Herceptin did not cause any side effects that I noticed. I should mention that I was only 32 when diagnosed so the nurses think my age may have helped me tolerate the harsh regiment. I am now 35 and have been NED for almost a year since completing all of the above. If you would like to contact me please feel free to email me at Bbeth69@aol.com. Good Luck!

Christa · New User Joined: 18 Feb 2005 Posts: 1

[b]Hi Anne, I'm Nancy's friend Christa---I was diagnosed with HerNeu++ and I'm taking taxotere and Xeloda---my understanding is that taxotere is pretty standard when you have the HerNeu++. I think your oncologist or chemotherapist is definitely on the right track.....

Regards
Christa[/b]

hhmv73a · Experienced user Joined: 16 Jan 2005 Posts: 95

Dear Annie,
I don't think the medical oncologists will give chemotherapy only because the Her2 was positive. Usually it depends on the TNM stage, differentiation (grade of the cancer), and ER/PR status.
Usually premenopausal females with negative ER/PR are not treated with hormonal therapy, and depends on the stage and differentiation, chemotehrapy may be indicated.
As far as I know, Herceptin is not indicated for early stage breast cancer even if the Her2 was positive. Since I am not a medical oncologists, you should talk to your treating oncologist to ask why chemotherapy is indicated in your case, and I am sure you will find a lot more informatin from him regarding your pathology and diagnosis.
Regards,
Jay
J. Jay Lu, M.D.
Diplomate, American Board of Radiology (Radiation Oncology)

Annie S · Regular Joined: 15 Feb 2005 Posts: 18

First thank you all for your responses to my questions of HER2NEU.
Second I must let you all know that I had called my Radiation Oncologist to let him know that my onco. wanted me to take Taxol (Taxenes) because as he had told me I was NER2NEU Post., well my Rad. Oncol. said he was looking at my reports and I am NOT POSTITVE but I am Negative. SHOCK. He was to call my oncol. to make sure he had the same paperwork and to ask what he had stating that I was Postitive. So now here is the next line of questions since I am so totally confused!!

My stats are as follows: Infiltrated Ductual Carsinoma

ER-, PR-, Her2-, Ki-67 60% (? I have no clue as to what that is) No Nodes were involved, margins clean, lumpectomy 3cm with 3 cm of clean tissue. I am 50 yrs. old Sentinal Node Biop. (3 nodes all clean), Premenapausal. I have three sessions of Adromyicin & Cytoxin w/Krtril (Alozi), Decadron, Ativan & Emend. I continue with Emend days 2 3 & 4 2 x's daily. Warafin (Blood thinner) daily. I am on Dose Dense of every 14 days. So now the burning question of ISN'T this ENOUGH treatment yet? Or is Taxol still necessary?
Thank you all again - Many Many HUGS :))
Annie S[/i]

hhmv73a · Experienced user Joined: 16 Jan 2005 Posts: 95

Dear Annie,

I think it is important to ask your medical oncologist whether more chemotherapy is indicated. The physician will use information from your physical examination, history, and path information to determine whether chemotherapy is needed or not. You should ask him about the differentiation of the tumor too since that is an important factor for further chemo or not. The T stage (your N seems to be negative) is also important.

Without a complete H and P, we cannot recommend any treatment for you over the internet. But you need to figure out the answers to these questions with your physicians.

Best wishes,

Dr. Jay LU

Annie S · Regular Joined: 15 Feb 2005 Posts: 18

Hello all, and thank you all so much for all your posts, comparisons, questions and answers to my post.

First of all it was an error on my Oncologist part of the Her2 I am negitive. My breast cancer is infiltrated ductual carsinoma with poorly differentated walls, stage IIA, er, pr neg. and node neg. with clear margins. Dr. Lu I am not sure of the other things you had asked in your post. I will have to write them down and question my doctor also.
Yesterday 2-21-05, could be my lst cycle of treatment. But my door is not closed. My Doctor has asked me to rethink the choices of 1. Another 2 cycles of the Adromyicin & Cytoxin or 2. 2 cycles of Taxene or Taxol. He also states that there is no conclusive information that any of this will be helpful or productuve. In 1 1/2 yrs there will be released a study as to node neg. women and the use of Taxol. But that is a bit far off yet. My Radiologist Oncologist suggests that Taxol while being node neg. is not necessary to do. And as I stated on the A & C well there is not much support to take additional 2 cycles. I was dose dense and recieved the highest amount that can be taken, I believe that was 240. So again I am out here looking questioning and wondering if this is the right choice to be finished.

Again many thanks, may the sun shine upon you all. Peace & Hugs
Annie S. of Long Island, NY

Annie S · Regular Joined: 15 Feb 2005 Posts: 18

Sorry - in the body of post I wrote lst cycle of treatment, that was to be LAST cycle of treatment. Spelling :(
<3 Annie S

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