Clinical trials

Kris · Posted: Mon Jan 29, 2007 3:22 pm Post subject: Clinical trials

Hi everyone, hello Michele, bc, Kevan, Brunette and all

I need to come back here to this forum regularly - you helped me through the hardest 4 months of my life.

Since Mum passed away in November, the biotech firm where I work in Geneva has been acquired by another firm, and interestingly - or oddly - they brought a new drug into our combined portfolio: cilengitide.

This new anti-GBM agent is in Phase II trials currently recruiting patients in the USA, it can be found on:
http://clinicaltrials.gov/ct/show/NCT00112866

God bless,
Kris

michelesmith · Experienced user Joined: 28 Oct 2005 Posts: 72

Kris,
It is good to hear from you, and good to hear there is something hopeful going on for this awful disease.

Michele
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Michele

Kris · Posted: Tue Jan 30, 2007 10:55 am Post subject: Re: Clinical trials

Dear Michele,

Yes it is promising to have new compounds in the pipeline for GBM therapy.

I feel a bit strange now that I'm working for a new company entity which strives for the treatment of GBM - unfortunately Mum had no time to wait for this merge - but I'm also proud of it and hopefully I can find a way to contribute to this work ... I wish I could help.

I think it can be useful for some eligible people to check out for currently recruiting GBM trials (with cilengitide, rituximab, temozolomide, etc.) on the clinicaltrials.gov site.

I remember you told me that time will help in reducing the pain, but I miss my Mom terribly and I'm still crying a lot. But at least, I have an aim, a target, a wish: to join GBM research.

Thanks for being there Michele, all my best,

Kris

bc · Experienced user Joined: 11 May 2006 Posts: 54

Hello all,

I hope all of you are doing well. My family and I are doing well. My mom has the biggest hurdles with continueing her life without my dad, whom she was married to for 49 years. But we are all here to support her and each other.

I still come here to read and help others who will be going through this. It is good to help others.

I just wanted to drop a quick note to say hi, and hope all are doing well

Bc

vintage · Regular Joined: 12 Jun 2006 Posts: 35 Location: Minnesota

Hi Kris! So glad you posted your info.!! I have bookmarked the site. Glad you are feeling a bit better every day.
Sure hope the study can help lots of people.
Keep in touch and please take care of yourself.

{{{{{hugs}}}}}

Kevan

My dear Dad diagnosed GBM IV 11/95. Died 12/31/96. 64 yo

Kris · Posted: Sat Feb 17, 2007 8:44 am Post subject: Re: Clinical trials

Dear Kevan, Michele, Bc

I'm always glad to hear your news.

Unfortunately I had real bad times recently, the adrenalin-driven "relief" phase just after my Mum's death ended in January, and I got into a sad, depressed and very tearful period - I was fulminently crying every evening when I got home from work, I was calling my mother desperately and I just could not stop ... it was tiring for myself, for my kids, for my husband, so I decided to go to see my GP who prescribed an anti-depression drug for me.

I'm doing much better since I'm taking this pill, but I hope I can get back to my good mood naturally, too.
I'm missing Mum terribly.

It's good to know you're all around, probably all of you having had gone through all the different phases after the loss of your beloved ones.

Thanks for listening,
Kris

michelesmith · Experienced user Joined: 28 Oct 2005 Posts: 72

Kris,
Don't be too hard on yourself. I am still grieving. Your timeline is exactly one year after mine it looks like--July-Nov 2005 for me. I still have times that are really hard, but it is better than it was this time last year. I cried pretty much multiple times of every day for a long while, now it is only weekly. When my 4 year brings me a picture of a truck and says, "This one looks like grandfather's doesn't it mommy", or we have something for dinner that dad loved or I see pictures of him holding the kids--there are still some hard days, but you can do it. Live each day in a way that you know your mom would be proud and you will make it through. We're here for you. We can make it knowing that there are others that are going through as hard of a time or worse. Thanks for all you have given to the forum.

Michele
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Michele

Kris · Posted: Fri Feb 23, 2007 11:28 am Post subject: Re: Clinical trials

Dear Michele,

You're right saying we all need sufficient time for grieving.

I understood with your help that I have to go through each step of grief from shock to anger, refusal, sadness, acceptance and finally a new phase when new actions and objectives can be set up for the future.
Hopefully I'll get through these phases once, and will not fall back from a higher to a lower, previous level.

Something I'm enthousiastic about is the results of the Phase II trials with cilengitide in GBM, which will be released in June at the ASCO Meeting in Chicago. I'll certainly give some news to the forum after the meeting. I hope science will move forward to overcome this horrific disease.

Michele, Kevan, bc, Sara, Jim, Chain, cgForrest, Brunette, Roxanne and all our friends on the forum, I think of you with lots of love and God bless you all.

Kris

Kris · Posted: Sat Jun 16, 2007 4:11 pm Post subject: Re: Clinical trials

Dear Friends,

I hate GBM. It took away my Mum. But, I'm a scientific person (I'm working at Merck Serono in Geneva), and I believe that one day we will eradicate this monster.

I'm happy to inform you that promising results have been presented at this year's ASCO meeting in Chicago with cilengitide in GBM.

More details at:
http://www.pharmalive.com/News/Index.cfm?articleid=4481

I'm glad to see that you're still on the forum, Michele, Kevan, and all ...

God bless,

Kris

michelesmith · Experienced user Joined: 28 Oct 2005 Posts: 72

Kris,
It is good to hear from you! Thanks for the post and link. While we may have lost our battles it is comforting to know that someday, some may be able to win. Before dad was diagnosed, I honestly had not known many with this disease, since that time, I have come into contact with so many that have loved ones with GBM. I wonder if this is something that is being diagnosed more frequently now than in the past. I personally have 2 very good friends who have lost close family to GBM in the past year.

Thanks for the hope!
Michele
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Michele

brainman · Posted: Mon Jun 18, 2007 1:19 pm Post subject: Re: Clinical trials

Kris, thank you for keeping us informed about this new drug. Drugs to treat GBMs have been so limited! I really hope that they will find one soon.

Michele, I don't know if GBM is more common now than in the past or if after seeing for the first time I am just more aware of it.
_________________
Jim
Site Administrator and long-term cancer survivor
1992 Astrocytoma grade 2, left motor strip
2005 Recurrence this time said to be an Oligodendoglioma grade 3, same location.
My Story Part 1: http://cancerforums.net/viewtopic.php?p=7350
My Story Part 2: http://cancerforums.net/viewtopic.php?t=8029
Blog http://jimhawkinsport.blogspot.com/

Kris · Posted: Tue Jun 19, 2007 4:07 am Post subject: Re: Clinical trials

Dear Jim,

You are a real Mentor for this site, for all of us. Thanks for being there.

Hi Michele,

I can only echo your view on the increasing number of GBM cases in our times. When Mum was still with us, her neurologist told us about the statistics of our region's (southern part of Hungary, close to the ex-Yugoslavian border) GBM cases and -what a terrifying info - they've DOUBLED since the last Serbian war. I believe that toxic materials, heavy-metals, rays, depleted uranium, etc. used in war situations are linked to this disease.

The other cause which more and more scientifics link to the development of GBM is the use mobile phones, mobile phone waves all over the world, above our head, as invisible ennemy.

Michele, we seem to have very similar destiny: at the company I work in Geneva, I just lost a colleague, MD, Head of Research, 54 yrs, due to GBM after 5 months of battle. Two weeks ago, I got the terrible news that another colleague, working at HR, 46 yrs, has been operated with GBM but did not well recover after surgery.

But, our task is to keep hope in everyone, and I do believe that with the new drugs in clinical trials one day we will win! That's why we have to stick together and fight against the disease by listening to our friends facing now GBM, by watching out for news and results which may give more and more hope.

Good to have you there, Michele and Jim!

Kris

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